A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Glutathione Depletion in Mitochondrial Diseases Glutathione Reporter Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Xia & He Publishing Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology
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glutathione depletion paracetamol Paracetamol-Induced Hepatotoxicity ⚠️, Overdose → ↑ NAPQI formation → Glutathione depletion → Liver cell necrosis. Early N-acetylcysteine (NAC) can save the liver., #Pharmacology #mbbs #Hepatotoxicity