Mechanism of paracetamol toxicity NUS Faculty of Science NUS Faculty of Science Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Are some people at increased risk of paracetamol induced liver injury? A critical review of the literature European Journal of Clinical Pharmacology Springer Nature Link