Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Hydrogen Water vs. Glutathione Reductase (GR): Which Is Better? Evolved H2O G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Glutathione: Role in Oxidative Nitrosative Stress, Antioxidant Defense, and Treatments Raj Rai 2021 ChemistrySelect Wiley Online Library The Protective Role of Glutathione on Zinc Induced Neuron Death after Brain Injuries Schematic representation of the role of the glutathione reductase enzyme. Download Scientific Diagram