Pathology of G6PD deficiency Pathology Made Simple G6PD Deficiency causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Understanding and Managing Glucose 6 Phosphate Dehydrogenase Deficiency ScienceDirect In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Glucose 6 Phosphate Dehydrogenase Deficiency (G6PD) Glucose 6 phosphate dehydrogenase deficiency Knowledge @ AMBOSS