Labial melanotic macule Pigmented Lesions and Melanoma Plastic Surgery KeyPlastic Surgery Key Melanotic Macules, Naevi, and Melanoma Springer Nature Link Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. COM Dec. 2011 Diagnosis UW School of Dentistry Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review