Frontiers The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches Understanding Activation and Protandim Nrf2 for Reducing Oxidative Stress Constantly getting asked about Protandim. Here is my response: Studies show it is helpful in reducing oxidative stress. I don't personally use it in my office, not necessarily because I don't like Activating the NRF2 Pathway in Dogs: A Practical Approach to Supporting Cellular Resilience & Longevity by Reducing Oxidative Stress The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies 5 Ways to Activate the Anti oxidant Benefits of Nrf2