Acetaminophen Intoxication: A Critical Care Emergency Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Efficacy of Oral N Acetylcysteine in the Treatment of Acetaminophen Overdose New England Journal of Medicine Acetaminophen Hepatotoxicity Clinics in Liver Disease Tylenol And Glutathione Invigor Medical
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