Clinical features of cutaneous melanotic nevihead and neck region. a Download Scientific Diagram From melanocytes to melanomas Nature Reviews Cancer Melanoma Pictures: Skin Changes and What to Look For ORAL MELANOTIC MACULE (OMM) (Also called focal melanosis labial melanotic macule) A benign, localized, flat pigmented lesion of the oral mucosa Caused by a focal increase in melanin production Despite the name "melanosis," the pigment isn't melanin. The Pigment: It is actually lipofuscin, a "wear and tear" pigment. The Process: Anthraquinone laxatives cause apoptosis (cell death) of the colonic epithelial cells. Oral Melanotic Macule: Symptoms and Treatment Skinsight